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Prion diseases. - Diagnosis and pathogenesis (Relié)
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Résumé
In this book twenty-seven invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.
Sommaire
- PATHOGENESIS OF PRION DISEASES
- Neurografts to neuroinvasion
- Follicular dendritic cells en scrapies pathogenesis
- Cellular and sub-cellular localisation of PrP in the Lymphoreticular system of mice and sheep
- Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice
- Pathogenesis of natural scrapie in sheep
- ANIMAL MODELS FOR PRION DISEASES
- Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrPc
- Analyzing the influence of PrP primary structure on prion pathogenesis en transgenic mice
- A single amino acid alteration in murine PrP dramatically alters TSE incubation time
- A transgenic model of a familial prion disease
- Transgenic models of prion disease
- EPIDEMIOLOGY AND DIAGNOSIS OF PRION DISEASES
- Surveillance of BSE
- Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs)
- Pathology of variant Creutzfeldt-Jakob disease
- Clinical and differantial diagnosis of Creutzfeldt-Jakob disease
- Putting prions into focus : application of single molecule detection to the diagnosis of prion diseases
- Detection of PrPsc in subclinical BSE with the parrafin-embedded tissue (PET) blot
- Sheep and goats : natural and experimental TSEs and factors influencing incidence of disease
- Application of Prionics Western blotting procédure K-resistant form of the prion protein using two-site immunometric assays, application to the post-mortem diagnosis of BSE
- CHARACTERIZATION OF THE INFECTIOUS AGENT
- PrPsc typing by N-terminal sequencing and mass spectrometry
- Characterization of BSE and scrapie strains/isolates
- Quantitatives traits of prion strains are enciphered in the conformation of the prion protein
- STRUCTURE AND FUNCTION OF PrP
- Function of PrPc as a copper-binding protein at the synapse
- The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations
- Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro
- PrP CONVERSION
- Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs
- The use of monoclonal antibody epitopes for tagging PrP in conversion experiments.
Fiche technique
- Date de parution : 18/01/2001
- Editeur : Springer
- Collection : springer life sciences
- ISBN : 3-211-83530-X
- EAN : 9783211835302
- Présentation : Relié
- Nb. de pages : 291 pages
- Poids : 1.075 Kg
- Dimensions : 21,5 cm × 28,5 cm × 1,6 cm
Prion diseases. - Diagnosis and pathogenesis est également présent dans les rayons
Prion diseases.. Diagnosis and pathogenesis
142,54 €