Hematopoietic Stem Cell, Transplantation and Cellular, Therapies for Autoimmune Diseases (Relié)

This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance.
This title provides information on different types of stem cells and immune cells ; post-transplant immune regeneration ; cellular regulatory requirements ; ethical and economic considerations ; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases ; autoimmune aplastic anemia ; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polÿneuropathy, neuromyelitis optics, and stiff person syndrome ; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus ; dermatologic diseases such as pemphigus ; gastrointestinal disorders such as Crohn's disease and celiac disease ; and immune-mediated endocrinologic disease type I diabetes mellitus.
Guidance is provided on the transplantation technique, cell, collection and processing, conditioning regimens, infections, and early and late complications. Key Features : Outlines therapies and techniques for HSCT for autoimmune diseases ; Discusses the advantages of HSCT over conventional therapies ; Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight.